Blar i forfatter "Skjesol, Astrid"

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    • IPNV with high and low virulence: host immune responses and viral mutations during infection 

      Skjesol, Astrid; SkjÆveland, ingrid; Elnæs, Marianne; Timmerhaus, Gerrit Frantz; Fredriksen, Børge Nilsen; Jørgensen, Sven Martin; Krasnov, Aleksei; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Infectious pancreatic necrosis virus (IPNV) is an aquatic member of the Birnaviridae family that causes widespread disease in salmonids. IPNV is represented by multiple strains with markedly different virulence. Comparison of isolates reveals hyper variable regions (HVR), which are presumably associated with pathogenicity. However little is known about the rates and modes of sequence divergence and ...

    • Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts 

      Sobhkhez, Mehrdad; Skjesol, Astrid; Thomassen, Ernst Ivan; Iliev, Dimitar Borisov; Sun, Baojian; Robertsen, Børre; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Mammalian IRF9 and STAT2, together with STAT1, form the ISGF3 transcription factor complex, which is critical for type I interferon (IFN)-induced signaling, while IFNγ stimulation is mediated by homodimeric STAT1 protein. Teleost fish are known to possess most JAK and STAT family members, however, description of their functional activity in lower vertebrates is still scarce. In the present study we ...

    • Structural and functional studies of STAT1 from Atlantic salmon (Salmo salar). 

      Shi, Cheng-Yin; Skjesol, Astrid; Hansen, Tom Egil; Thim, Hanna Leena; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • Studies of infectious pancreatic necrosis virus (IPNV) and immune evasion strategies 

      Skjesol, Astrid (Doctoral thesis; Doktorgradsavhandling, 2009-10-23)
      Infectious pancreatic necrosis (IPN) is a highly contagious disease which causes huge economic loss to the salmon farming industry world wide. The causative agent, the IPN virus (IPNV), is a dsRNA, non-enveloped virus with two genomic segments encoding five viral proteins, VP1-VP5. <br>Available vaccines against this disease give only partial protection. In order to optimize vaccine efficacies, ...